GeneChem Inc. is the South Korean company specialized in the production of sialylated oligosaccharides and glycosylation of bioactive molecules through its unique and efficient enzyme based platform technology.
GeneChem is the only manufacturer of high purity Siallac3® (3'-sialyllactose sodium salt) and Siallac6® (6'-sialyllactose sodium salt) on a commercial scale for food applications.
GeneChem has completed the self-affirmed GRAS evaluation of Siallac3® and Siallac6® and those products are now available for the development of nutritional products for various health-aid applications.
Sialyllactaose (SL) is an acidic milk oligosaccharide which has N-acetyl neuraminic acid (sialic acid, Neu5Ac) connected to penultimate galactoside residue. 3'-Sialyllactose (3'-SL) and 6'-Sialyllactose (6'-SL) are two most abundant isomers of SL in human milk. 6'-SL is the major SL in human milk whereas 3'-SL is the major one in bovine milk. Concentration of 6'-SL in human milk decreases with time, whereas that of 3'-SL remains fairly stable. Since concentration of sialyloligosaccharides in bovine milk is much lower than that in human milk, the bovine milk based typical infant formula is estimated to contain less SLs.
Physiological Benefits of SL: - Prebiotic Effect:
- SL acts as prebiotic, promoting the growth of beneficial gut microbes, such as Bifidobacteria and lactic acid producing bacteria.
- Pathogen Prevention:
- SL when present in the gut, binds to pathogens acting as soluble receptor decoys, in that way preventing pathogen adhesion and invasion.
- Brain & Cognitive Development:
- Research suggest that supplementation of SL may positively affect neonate, serving as a source of sialic acid for neurologic development.
- SL plays direct role in the postnatal maturation of the immune system.
- Muscle development:
- SL plays an important role in healthy growth of the musculoskeletal system.
- Cartilage regeneration: SL promotes cartilage regeneration and inhibits cartilage degradation thereby protecting joint cartilage from destruction.