Natural Ingredients and Products Directory is part of the Informa Markets Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC's registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

Gnosis by Lesaffre

United States

Gnosis by Lesaffre, a business unit of Lesaffre, is a world expert in yeast, bacteria and pure molecule from fermentation, dedicated to human health and nutrition. The company aspires to be a trusted innovation partner for its clients in the pharmaceutical, nutritional and functional food industries, and to assist them in helping consumers lead healthier and happier lives.

From nutritional and fortified yeasts to yeast fractions, probiotic yeasts and bacteria, vitamin or pure molecules, Gnosis by Lesaffre develops and supplies innovative solutions and ingredients of natural origin with scientifically proven efficacy to target a wide range of applications: digestive health, bone protection, immunity enhancement, joints and liver health, women health, vegetarian support and overall wellbeing. The broad range of differentiating solutions aims at improving and boosting human health by bringing to our diet bioactive nutrients. 

Gnosis by Lesaffre products are designed for dietary supplements, functional foods, drugs or medical devices. Gnosis by Lesaffre is a trustful partner for dietary supplements marketers for decades, remaining the core-business of the business unit. Gnosis by Lesaffre has been able to develop its production practices to produce APIs (Active Pharmaceutical Ingredients) under GMP certification. Gnosis by Lesaffre also offers its expertise in the implementation of its ingredients in functional food applications thanks to its applications lab.   

Gnosis by Lesaffre offers a broad portfolio of ready-to-use solutions of natural origin covering a broad spectrum of applications:



Quatrefolic® - The 4th generation folate  
The (6S)-5-methyltetrahydrofolate glucosamine salt is the innovative folate that the body can immediately use without any kind of metabolizing. Useful at various stages of life, active folate contributes to maternal tissue growth during pregnancy, to normal amino acid synthesis, blood formation

VitaMK7® - The natural vitamin K2 as MK7
The vitamin K2 as MK7, produced naturally through a patented fermentation process of Bacillus subtilis natto (soy-free) and within our own European cGMP approved plant, is a safe and effective support to bones and cardiovascular health of women and men, from childhood to old age. 

Mythocondro® - The Non-Animal Chondroitin Sulfate
The first and only Non-Animal Chondroitin Sulfate (CS) obtained through a fermentation-based manufacturing process. As a support of joint health, Mythocondro® solves any concerns related to the production origin, the possible presence of transmissible infective agents, the contaminations and adulterations typical of animal-derived raw materials and promises to completely change the global CS industry. Once-a-day dose efficacy and safety clinically proven.



IbSium® - The breakthrough for complete intestinal support

An exclusive beneficial live yeast (Saccharomyces cerevisiae CNCM I-3856) patented by Lesaffre and designed to reduce intestinal pain, bloating and constipation. Its effectiveness has been demonstrated on more than 1700 volunteers including 600 during clinical studies. 

Quatreflora™ - Your ally to support healthy vaginal microflora

Quatreflora™ is an innovative and patented range of solutions of natural origin from beneficial yeast to support healthy balance of vaginal microflora. Discover the science behind it with several peer-reviewed publications explaining its mechanism of action and clinical efficacy.

LifeinU™ L. rhamnosus GG - An alternative source of high-quality L. rhamnosus GG

With more than 1200 scientific publications and 300 clinical studies, L. rhamnosus GG is one of the most studied probiotic bacteria. It has shown beneficial effects on both digestive and immune health. LifeinU™ L. rhamnosus GG is a high-quality source of Lactobacillus rhamnosus GG.


S. boulardii

A probiotic yeast (Saccharomyces cerevisiae var. boulardii) with clinically proven beneficial effect on digestive health. It can help maintain or restore a balanced gastrointestinal flora.


Lynside® Nutri - The traditional Superfood      
Used by consumers around the world fo


  • Quatrefolic®
  • Vitamk7®
  • Proteyn®
  • K2&Olive
  • Mythocondro®
  • IbSium®
  • Phosphocomplex
  • Adogran
  • Emothion®
  • Quatreflora™
  • Adonat®
  • Biootic®


Stable salts of S-Adenosylmethionine and process for the preparation thereof
The present invention refers to new salts of S-adenosylmethionine (SAMe) with improved stability and containing at least 70% by weight of SAMe.
Patent Number: US 8,258,115 | Patent Date: 09/04/2012
Process for the preparation of pharmaceutically acceptable salts of (SS-RS)-S-Adenosyl-L-Methionine
The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (R,S)-S-Adenosyl-L-Methionine and allows to obtain the salified ( R)-(+)-S-Adenosyl-L-Methionine diasteroisomer in amounts lower than or equal to 3% with respect to the salified (S)-(+)-S-Adenosyl-L-Methionine diasteroisomer; the salts that can be obtained by the process of the invention keep their configuration stable in time.
Patent Number: US 6,958,233 | Patent Date: 10/25/2005
Process for the preparation of tablets comprising S-Adenosyl-L-Methionine
The present invention provides a process for the preparation of tablets comprising S-Adenosylmethionine and/or a pharmaceutically and/or dietarily acceptable derivative thereof by blending that active component with specified additives, compressing the blend, followed by coating.
Patent Number: US 7,087,587 | Patent Date: 08/08/2006
A process for the preparation of Vitamin K2
A process for the preparation of vitamin K2 (MK-7) comprising the culture of Bacillus subtilis mutant strain GN13/72DSM 17766 deposited on Dec. 5, 2005 at the DSMZ.
Patent Number: US 7,718,407 | Patent Date: 02/22/2010
Folates, compositions and uses thereof
The present invention relates to folates, compositions and uses thereof; In particular, this invention describes a crystalline or amorphous compound which is a substituted or unsubstituted folate or a reduced folate, or the natural or unnatural isomers thereof, of at least one organic base, as well as compositions and uses thereof. The compounds of the invention show a long lasting stability as well as a peculiarly high watr-solubility.
Patent Number: US 7,947,662 | Patent Date: 05/24/2011
Process for producing glutathione
There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione producing yeast where in the glutathione content per biomass unit is higher than 1.2% w/w; (b) the cultivation, in aerobic conditions, of the resulting biomass pre-culture such that the resulting biomass density is higher than 50 g/l; (c) the activation of the cultured biomass; and (d) the recovery of the cultured biomass, extracting glutathione at a pH equal to or lower than 6 and purifying the resulting glutathione. The process allows to obtain glutathione with high yields and relatively low costs.
Patent Number: US 6,902,912 | Patent Date: 06/07/2005
Dried or freeze-dried and/or microencapsulated Saccharomyces cerevisiae cells with a high content of (S)-(+)-S-Adenosyl-L-Methionine, process for their preparation, and compositions containing said ce
Disclosed are dried and/or microencapsulated Saccharomyces cerevisiae cells with a high content of (S)-(+)-S-Adenosyl-L-Methionine, in the form of a free base obtainable from selected high-productivity strains of (S)-(+)-SAMe.
Patent Number: US 9,365,817 | Patent Date: 06/14/2016