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Madera, CA 93637
United States

Polyphenolics was founded in 1996 as a nutritional ingredient business within Constellation Brands, one of the world’s largest wine companies. As a division of Constellation Brands, Polyphenolics has an abundant supply of California wine grapes.
Polyphenolics is a science-driven organization dedicated to researching and developing innovative products using grape-seed-derived polyphenols to deliver specific and documented health benefits.

Key Personnel
James A. Kennedy, Ph.D., President
Steve Kupina, M.S., Director of Quality and Technology
Gregory Arabatzis, Director of Global Sales
Mark Kelm, Ph.D., Director, Research and Development        
Jessica Ornelas, Customer Service Advocate
Debra Cerda, Marketing Specialist

Polyphenolics’ MegaNatural®  grape seed and pomace extracts are FDA No-Objection GRAS.

Polyphenolics maintains current quality management systems including ISO, Cal OSHA programs and third party certifications. Polyphenolics retains complete control over the entire manufacturing process. Polyphenolics goes beyond federally mandated traceability requirements, documenting all aspects of growing, treating, and handling the varietal grapes. Through painstaking supply chain documentation and laboratory testing, Polyphenolics can substantiate freshness, identity, domestic origin, and absence of chemical contaminants and genetic modification.

Technologies, Patents/Intellectual Property
US Patent 6,544,581 B1 Unique hot water extraction process eliminates the use of industrial solvents.
US Patent 7,651,707 B2 Method for lowering blood pressure in pre-hypertensive individuals (MegaNatural®-BP).
US Patent 7,767,235 B2 Composition of MegaNatural®-BP
US Patent 8,075,929 B2 Exclusive production process.
Various international patents have been granted with others pending.

Major Markets
Dietary Supplements, Functional Beverages, Functional Foods

Major Products
MegaNatural®-BP Grape Seed Extract - Antioxidant activity, Blood Pressure Maintenance, Sports Nutrition
MegaNatural®-Gold Grape Seed Extract - Antioxidant activity, Sports Nutrition
MegaNatural®-GSKE Grape Pomace Extract
MegaNatural®-Whole Red Grape Juice Extract
MegaNatural®- Red Wine Grape Extract
MegaNatural®- Red Wine Grape Extract with trans-Resveratrol

Polyphenolics is currently working on expanding the MegaNatural® line of condition-specific extracts.


  • MegaNatural®-BP grape seed extract
  • MegaNatural®-Gold grape seed extract


  • American Botanical Council (ABC)
  • Council for Responsible Nutrition (CRN)
  • Institute of Food Technologists (IFT)


Process for extraction, purification and enrichment of polyphenolic substances from whole grapes, grape seeds and grape pomace
Water Extraction - Unique Process for making MegaNatural grape extracts
Patent Number: 6,544,581 B1 | Patent Date: 04/08/2003
Method for lowering blood pressure in pre-hypertensive individuals and/or individuals with metabolic syndrome
UC Davis Method of Use for MegaNatural-BP
Patent Number: 7,651,707 B2 | Patent Date: 01/26/2010
Grape extract, dietary supplement thereof, and processes therefor
Composition of MegaNatural-BP
Patent Number: 7,767,235 B2 | Patent Date: 08/03/2010
Grape extract, dietary supplement thereof, and processes therefor
Process for MegaNatural-BP Production
Patent Number: 8,075,929 B2 | Patent Date: 12/13/2011
Methods for Preventing and Treating Neurodegenerative Diseases
The present invention provide a method for the prevention and treatment of a neurodegenerative disease including Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease, using a grape seed extract (MegaNatural-AZ) or one or more compounds derived therefrom. In particular, the present invention provides a method to treat a patient diagnosed with, or at the risk of developing, a neurodegenerative disease by administering a pharmaceutical composition comprising a grape seed extract or one or more compounds derived therefrom to the patient in a therapeutic amount to reduce the accumulation, aggregation or deposition of amyloid beta or its oligomers, and/or to reduce the misfolding, accumulation and/or aggre gation of tau proteins or other proteins.
Patent Number: 8,747,924 B2 | Patent Date: 06/10/2014


Grape Seed Extract

MegaNatural® Red Wine Grape Extract