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µsmin®Plus: Bio-enhanced Micronized Diosmin

Proprietary flavonoids complex with enhanced bioavailability.


Diosmin, a citrus flavonoid derived from hesperidin, is used for treating acute internal hemorrhoids, preventing relapse of acute internal hemorrhoids, treating varicose veins, venous stasis, subconjunctival and retinal hemorrhage, lymphedema following breast cancer surgery, venous stasis, and gingival bleeding. Diosmin has also been used to protect against liver toxicity.

Active: diosmin (NLT 90% tot. flavonoids).

Extract Type: micronized granulated powder.

Recommended Dosage: 300 – 900 mg/day.

Applications: powders, tablets, hard shell capsules.


Proprietary blend of flavonoids

9x greater absorption than ordinary micronized diosmin

Pre-clinical and clinical pharmacokinetics

Improved conversion in the active aglycone form

With an acid-buffering system

Great flowability and compressibility



Pharmacokinetic profile of µsmin® Plus, a new micronized diosmin formulation, after oral administration in rats (Russo et al 2015). Comparative Bioavalaibility of Two Diosmin Formulations after Oral Administration to HealthyVolunteers (Russo et al 2018).

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