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Bacopa monnieiri extract USPBacopa monnieri extract by UV

Bacopa monnieir extract 45% USP

Bacopa for Brain Health

 

What is Bacopamonnieri? 

Bacopa monnieriLinn. is a ayuvedic herb belonging to the family Schrophulariaceae. It is commonly known as “Brahmi”. It has been used in Ayurveda since time immemorial and is mentioned in traditional books of Ayurveda like Charaka Samhita, and Susurtu Samhita.1Brahmi belongs to the class of medhya rasayana, a class of drugs used for promoting mental health and amelioration of memory.2In ayurveda, it is also mentioned for the treatment of epilepsy, asthma, ulcers and tumours.1

Bacopa is a perennial, creeping herb with numerous branches, small oblong leaves and white or purple flowers. It grows well in wet, damp and marshy places. It is native to India and Australia and also found growing in United States and East Asia (Barrett and Strother, 1978).3

Bacopa extracts contain various biochemical compounds such as alkaloids, bacosides, flavonoids, glycosides, triterpenoids and saponins etc. The major therapeutic constituent being triterpenoid saponins called Bacoside A and B.1Bacoside A is a blend of bacoside A3, bacopacide II, bacopasaponin C, and a jujubogenin isomer of bacosaponin C.4

Mechanism of action:

Modern studies have found bacopa to act via various mechanisms like anti-oxidant neuroprotection, acetylcholinesterase inhibition, choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation.5

Clinical Evidences

Memory enhancing effect in healthy volunteers

In a double-blind placebo-controlled study conducted by Stough C et al 62 healthy participants were administered placebo or Bacopa extract (300 mg/day) for 90 days. Bacopa extract significantly improved performance on the 'Working Memory' factor, more specifically spatial working memory accuracy (Fig. 1).6 Results of the study were similar to previous study findings of cognitive enhancing effects in healthy subjects following administration of Bacopa extract.7,8

Memory enhancing effect in child and adolescents

Clinical trial conducted in children requiring individual attention programme, administration of Bacopa extract (225 mg/day) for four months showed significant improvement in working memory and short term verbal memory (Fig. 2).9

In an another clinical trial in children with ADHD, administration of Bacopa extract (225 mg/day) for six months showed reduced symptom scores for restlessness in 93% of children and improvement in self-control in 89% of children. Attention deficit symptoms were reduced in 85% of children. Similarly, symptom scores for learning problems, impulsivity, and psychiatric problems were reduced for 78%, 67%, and 52% of children, respectively.10

Memory enhancing effect in older persons

Randomized, double-blind, placebo-controlled trial conducted in healthy older persons showed administration of Bacopa extract (300 mg/day) for 3 months to significantly improved verbal learning, memory acquisition, and delayed recall.11

Barbhaiya et al conducted randomized double blind placebo controlled study in elderly participants with complaint of memory impairment of at least one year. Bacopa extract or placebo was given as a single oral dose of 450 mg daily for the duration of 12 weeks. Bacopa extract improved performance in tests associated with attention and verbal memory in elderly participants (Fig. 3).12

Safety

Bacopa has been used safely in Ayurveda for several hundred years. Safety of Bacopa is time-tested.13

Animal studies:In rats, LD50of Bacopa water extract was 5 g/kg and alcoholic extract was 17 g/kg.13Even in the 90-day oral toxicity study in rats, Bacopa exhibited a no-observed adverse effect level (NOAEL) of 500 mg/kg and LD50of 2400 mg/kg.14

Human studies:In phase I study conducted in healthy male volunteers concentrated bacosides were administered in single (20-30 mg) and multiple (100-200 mg) doses daily for 4 weeks.2Both the doses were well tolerated without adverse effects. In an another Phase I study, 23 adults were given one single capsule of Bacopa extract for 30 days (300mg for first 15 days and 450 mg for next 15 days), and in this study Bacopa extract was found to be safe and well tolerated in healthy adult volunteers.15

Why Bacopa extract from Botanic Health Care?

Chromatographic standardization based on Bacosides content.

The product is Kosher certified.

Manufactred in a GMP, ISO 9001-2000 and ISO 22000 certified manufacturing facility.

Availability:Bacopa monniera extract standardized to Bacosides (≥50% w/w)

Dose:300 to 450 mg/day/adult; 225 mg/day/children

*Disclaimer: “These statements have not been evaluated by Food and Drug Administration or any other health authority. This product is not intended to diagnose, treat, cure or prevent any disease.”

References

Rai K et al. (2017) Int. J. Appl. Sci. Biotechnol.; 5(2): 127-132.

SINGH HK et al. (1997) Indian Journal of Pharmacology; 29: S359-S365.

Bacopa monniera. (2004) Alternative Medicine Review; 9(1): 79-85.

Deepak M et al. (2005) Phytochemical Analysis; 16(1): 24-29.

Aguiar S et al. (2013) Rejuvenation Research; 16(4): 313-326.

Stough C et al. (2008) Phytother Res.;22(12): 1629-1634.

Stough C et al. (2001) Psychopharmacology; 156(4): 481-484.

Roodenrys S et al. (2002) Neuropsychopharmacology.;27(2): 279-81.

Usha PD et al. (2008) Journal of Pharmacology and Toxicology; 3: 302-310.

Dave UP et al. (2014) Adv Mind Body Med.; 28(2):10-5.

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