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Coleus forskholii extract Coleus forskholii extract 10%

Coleus forskholii extract

What is Coleus forskholin? 

Coleus forskohliiis a perennial herb belonging to the mint (Lamiaceae) family. Coles roots has been used since ancient times in Ayurveda. Historically, it has been used to treat hypertension, congestive heart failure, eczema, colic, respiratory disorders, painful urination, insomnia, and convulsions.1

 Coleus is a perennial herb and grows in the subtropical temperate climates of India, Nepal, Sri Lanka, and Thailand. Plant height is approximately 1-2 feet and its striking leaves are teardrop shaped, shimmering green framing a bright purple center; leaf colour varies depending on the amount of shade. The rootstock is typically golden brown, thick, fibrous, and radially spreading. The roots are harvested in the fall, when forskolin is at its most concentrated and the colour is the brightest.1

Major therapeutic constituent of Coleus forskohliibeing Forskolin, a diterpene. Forskolin is responsible for virtually all pharmacological activities attributed to Coleus forskohlii.1

Mechanism of action:

Primary mode of action of Forskolin is to increase cyclic adenosine monophosphate (cAMP) and cAMP mediated functions, via activation of the enzyme adenylate cyclase. Forskolin has been shown to increase cAMP formation without hormonal activation of adenylate cyclase. It’s potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, stimulates lipolysis in fat cells, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion.

Clinical Evidences

Godard et al, conducted a double-blind, placebo-controlled clinical trial in overweight and obese men to examine the effect of Coleus extract supplementation on body composition, testosterone, metabolic rate, and blood pressure. In this study, 30 subjects supplemented their diet with Coleus 10% extract (250 mg) or a placebo two times a day for 12 weeks. Supplementation of Coleus extract significantly reduced fat mass (Fig. 1) in overweight and obese men.  The results indicate Coleus extract to be a possible therapeutic agent for the management and treatment of obesity.2 Henderson et al, conducted a double blind, placebo controlled, randomized clinical trial in mildly overweight women to determine the safety and efficacy of Coleus extract supplementation. In this study, 23 females supplemented their diet with Coleus 10% extract (250 mg) or a placebo two times a day for 12 weeks. Effectiveness of Coleus extract on body composition measured using dual-energy x-ray absorptiometry (DEXA) and general markers of health were noted. The findings showed that supplementation of Coleus extract for 12 weeks in free-living subjects had limited effects on body composition. Figure 2 highlights differences in DEXA lean mass (g) at different time intervals in coleus and placebo groups. Coleus extract supplementation helped to mitigate weight gain in overweight females.3

Safety

Animal studies:In acute, sub-acute, chronic oral toxicity studies of Coles extract (10% forskolin) with Wistar rats, no deaths were reported, no significant changes observed in the hematology and serum biochemistry values, the body weight changes and necropsy results were normal, no apparent progression of organ damage in any of these toxicity studies. Even ames test performed to evaluate the mutagenicity of test substance was negative. The NOAEL was determined to be above 1000 mg/kg/day.4

 

Human studies:In clinical studies conducted in male and female overweight and obese subjects, supplementation of coleus extract 10% for 12 weeks at dose of 250 mg twice daily did not show any clinically significant adverse effects.2,3

Superior quality Coleus forskohlii extract from Botanic Health Care!

Chromatographic standardization based on Forskolincontent.

The product is Kosher certified.

Manufactred in a GMP, ISO 9001-2000 and ISO 22000 certified manufacturing facility.

Availability: Coleus forskohlii extract standardized to Forskolin(≥10% to 98% w/w)

Dose:500 mg/day/adult in two divided doses Foskohlin 10%

*Disclaimer: “These statements have not been evaluated by Food and Drug Administration or any other health authority. This product is not intended to diagnose, treat, cure or prevent any disease.”

References

Coleus forskohlii. Alternative Medicine Review. 2006; 11(1): 47-51. 

Godard MP et al. Obesity Research, 2005; 13(8): 1335-1343.

Henderson S et al. Journal of the International Society of Sports Nutrition. 2005; 2(2): 54-62.

Majeed M et al. IJPPR.Human, 2015; 5 (1): 219-238.

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