Lipid And Liquid-Based Formulations
Lipid and Liquid-based formulations (LBF) based on oils, surfactants and cosolvents represent a robust approach for improving bioavailability in either liquid-filled hard capsules or soft-gelatin capsules. Liquid and semi-solid fill technologies are well suited to compounds with low aqueous solubility or poor permeability and have long-established market precedence. Lipidic vehicles are generally well absorbed from the gastrointestinal tract, providing better oral bioavailability than can be achieved with the solid drug substance. We have expertise using oil-based and oil-free formulation approaches, as well as self-emulsifying vehicles, as shown in the table below. Formulation types are based on the Lipid Formulation Classification System (LFCS).