Nattozimes® Enzymatic Alternative to Nattokinase A healthy diet and exercise are clearly important to cardiovascular health, but including supplemental enzymes can also be beneficial as part of a heart healthy lifestyle. Human studies have found that the enzyme nattokinase may be effective in promoting healthy blood pressure and may reduce clotting factors to help support cardiovascular health. Nattokinase is a naturally-occurring protease enzyme from the popular Japanese dish made of fermented soybeans known as natto. Modern research initiated by Dr. Hirouki Sumi identified the active principle in natto to be a protease produced by the fermenting organism Bacillus subtilis. Researchers have discovered that this protease supports heart health through improved circulation. The enzyme was named nattokinase, and it is now used therapeutically in Japan.