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TLC-MS Interface 2

TLC-MS Interface 2


The elution-based CAMAG TLC-MS Interface 2 is a highly convenient
and versatile instrument allowing for rapid and contamination-
free elution of TLC/HPTLC zones with online transfer to
a mass spectrometer. Through the pioneering concept of hyphenating
high-performance thin-layer chromatography with mass
spectrometry unequivocal substance identification is possible.
The CAMAG TLC-MS Interface 2 can be installed plug & play
with any LC-MS system without adjustments or mass spectrometer
modifications. Depending on the MS system, a substance
can be identified within a minute via its mass spectrum, or for
an unknown substance zone, the respective sum formula can
be obtained. Furthermore, interesting zones can be eluted into
vials for further investigations with, e.g., NMR, (ATR-)FTIR,
The chromatogram zones are eluted from the HPTLC plate
with methanol or another suitable solvent with the flow speed
appropriate for the LC-MS system. The round elution head is
used for circular zones and the oval elution head for zones
in the form of bands. After elution the eluate is either transferred
online to the mass spectrometer or collected in a sample
vial for further offline analysis.
The CAMAG TLC-MS Interface 2 features a modified elution
head and an easily accessible, exchangeable filter, arranged in
front of the valve. Cleaning is facilitated as compared to the
previous version, making it highly efficient. By pushing a button,
the elution path is cleaned of matrix particles with compressed
air, increasing the lifetime of the filter and preventing the system
from becoming blocked. Filters can be easily replaced without
any modification to the elution head.
Plate positioning is significantly simplified: together with the
positioning scale and the adjustable plate-stopper, the integrated
crosshair laser enables accurate and reproducible positioning
of the plate. Alternatively the coordinates determined
by the CAMAG TLC Visualizer or the CAMAG TLC Scanner can
be used to precisely position the HPTLC plate.

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